Advances in Immunology

Micromanagers of immune cell fate and function.

MicroRNAs (miRNAs) regulate cell fate during development and in response to environmental cues. Here, we review the emerging story of how miRNAs regulate immune cell development and function.

Tumor immunology: multidisciplinary science driving basic and clinical advances.

The fourth AACR Special Conference "Tumor Immunology: Basic and Clinical Advances" was held in Miami, FL in December 2012. The overall objective of this meeting was to discuss emerging concepts in cancer immunology and immunotherapy. The key findings that emerged from this meeting included: (i) multiple immune checkpoints should be inhibited to increase effective T-cell therapy, (ii) successful...

Therapeutic use of immunoglobulins.

E. Richard Stiehm, MD*, Jordan S. Orange, MD, PhD, Mark Ballow, MD, Heather Lehman, MD Division of Immunology/Allergy/Rheumatology, Mattel Children’s Hospital, UCLA School of Medicine at UCLA, CA, USA Division of Immunology, Children’s Hospital of Philadelphia, University of Pennsylvania School of Medicine, PA, USA Division of Allergy, Immunology and Pediatric Rheumatology, Women & Children’s H...

Recent Advances in Mucosal Immunology and Ocular Surface Diseases

Biological response modifiers in human oncology and immunology.

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Mechanisms of immune evasion by tumors.

In the past decade, basic studies in animal models have begun to elucidate the physiological barriers which impede a successful antitumor immune response. These barriers operate at a number of levels, and involve the tumor, the tumor microenvironment and various components of the innate and adaptive immune systems. In this review, we discuss the multiple mechanisms by which tumors evade an immu...